Sierra Leone Trial to Introduce a Vaccine against Ebola (STRIVE): In 2014, eHealth Africa was approached by the U.S. Centers for Disease Control and Prevention (CDC) to assist in the implementation of the first-ever clinical trial in Sierra Leone. The clinical trial was to test a vaccine against the Ebola Virus Disease. At the time Sierra Leone was facing a deadly Ebola outbreak.

 
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countries

Sierra Leone

funding

United States Centers for Disease Control & Prevention

 
Remaining supplies/equipment purchased under the contract were declared to CDC using the SF-1428. The Equipment were given to the MOHS to help maintain a national cold chain

Remaining supplies/equipment purchased under the contract were declared to CDC using the SF-1428. The Equipment were given to the MOHS to help maintain a national cold chain

Participant files stored for 5 years at the study site following the conclusion of the trial.

Participant files stored for 5 years at the study site following the conclusion of the trial.

Objective:

Sustained long-term facility for the STRIVE participant clinical trial records that meet mandated regulatory storage requirement.

Project Details:

In 2014, eHealth Africa was approached by the U.S. Centers for Disease Control and Prevention (CDC) to assist in the implementation of the first-ever clinical trial in Sierra Leone. The clinical trial was to test a vaccine against the Ebola Virus Disease. At the time Sierra Leone was facing a deadly Ebola outbreak.

In the end, STRIVE enrolled and vaccinated over 8,000 health care and front-line workers. 350+ Sierra Leonean clinicians were trained to enroll, vaccinate, and provide surveillance, also building a functioning cold chain to support -80 degree centigrade temperatures to keep the vaccine viable.

eHA facilitated the construction and maintenance of a climate controlled warehouse to maintain physical records of more than 8,000 participants of STRIVE. eHA’s ICT Technicians provided technical assistance to the Ministry of Health and Sanitation and College of Medicine and Allied Health Sciences (COMAHS).

eHA also works with Technical Resources International Inc (TRI) to maintain electronic clinical data.

The vaccine trial eHealth did significant renovations to sections of Connaught, Port Loko and Magburaka Government Hospitals and COMAHS Conference Center

The vaccine trial eHealth did significant renovations to sections of Connaught, Port Loko and Magburaka Government Hospitals and COMAHS Conference Center

eHA will continue to work with the COMAHS to prepare for a United States Federal Drug Administration (FDA) audit of the participants, as required for licensure of the Ebola Vaccine used in STRIVE.

The intended outcome is sustained long-term storage facility for the STRIVE participants clinical trial.

eHA's role

eHA’s role is to complete regulatory requirements for the storage of participant data mandated for clinical trials. Here are some of the innovations eHealth Africa facilitated for the STRIVE program:

  • Provide logistics and technical support to the Long Term Storage.

  • A mobile electronic participant registration system.

  • A toll-free line hosted by a 24-hour call center for participants enrolled in the trial.

  • Operations and logistics support to the seven enrollment and vaccination sites.

  • Renovation of the enrollment and vaccination sites prior to opening.

  • Contract creation with hospitals around the country to provide free medical care to 8000+ enrolled participants for the duration of the trial.

who benefits
 
  • Government of Sierra Leone

  • Wide Global Public

 
Impact
 

8,700

health care workers and frontline workers were vaccinated against Ebola Virus Disease in Western Area, Port Loko, Bombali and Tonkolili Districts.

 
 
Success story
 
 
 
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partners
 
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